2,3-Di(furan-2-yl)quinoxaline (Compound 5) is a quinoline with blue fluorescence. 2,3-Di(furan-2-yl)quinoxaline is cell permeable (penetrable) and sufficiently bright at micromolar concentrations (1.5 μM).

Physicochemical Properties

Molecular Formula	C16H10N2O2
Molecular Weight	262.26
Exact Mass	262.074
CAS #	57490-73-0
PubChem CID	236275
Appearance	Light yellow to yellow solid powder
Density	1.272g/cm3
Boiling Point	360.5ºC at 760mmHg
Flash Point	117.2ºC
Index of Refraction	1.637
LogP	4.149
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	2
Heavy Atom Count	20
Complexity	306
Defined Atom Stereocenter Count	0
InChi Key	GMUROSQCXMKHEN-UHFFFAOYSA-N
InChi Code	InChI=1S/C16H10N2O2/c1-2-6-12-11(5-1)17-15(13-7-3-9-19-13)16(18-12)14-8-4-10-20-14/h1-10H
Chemical Name	2,3-bis(furan-2-yl)quinoxaline
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Green Hydrothermal Synthesis of Fluorescent 2,3-Diarylquinoxalines and Large-Scale Computational Comparison to Existing Alternatives. ChemSusChem. 2021 Apr 22;14(8):1853-1863.

Solubility Data

Solubility (In Vitro)

DMSO: 100 mg/mL (381.30 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (9.53 mM) (saturation unknown) in 10% DMSO + 40% PEG300 +5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 + to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.8130 mL	19.0650 mL	38.1301 mL
	5 mM	0.7626 mL	3.8130 mL	7.6260 mL
	10 mM	0.3813 mL	1.9065 mL	3.8130 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.