2,2,14,14-Tetramethyl-8-oxopentadecanedioic acid is a ketone compound. For more details, check and find compound II-9 from the patent WO2002030860A2. 2,2,14,14-Tetramethyl-8-oxopentadecanedioic acid is available Research on cardiovascular diseases, dyslipidemia, protein abnormalities and glucose metabolism disorders.

Physicochemical Properties

Molecular Formula	C19H34O5
Molecular Weight	342.47
Exact Mass	342.24
CAS #	413624-71-2
PubChem CID	11336822
Appearance	Typically exists as solid at room temperature
Melting Point	82 - 83 °C
LogP	4.3
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	14
Heavy Atom Count	24
Complexity	386
Defined Atom Stereocenter Count	0
SMILES	CC(C)(CCCCCC(=O)CCCCCC(C)(C)C(O)=O)C(O)=O
InChi Key	NHVXRVOYVVPVDU-UHFFFAOYSA-N
InChi Code	InChI=1S/C19H34O5/c1-18(2,16(21)22)13-9-5-7-11-15(20)12-8-6-10-14-19(3,4)17(23)24/h5-14H2,1-4H3,(H,21,22)(H,23,24)
Chemical Name	2,2,14,14-tetramethyl-8-oxopentadecanedioic acid
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Jean-Louis H. Dasseux, et al. Ketone compounds and compositions for cholesterol management and related uses. WO2002030860A2.

Solubility Data

Solubility (In Vitro)

DMSO: 100 mg/mL (292.00 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (7.30 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (7.30 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 2.5 mg/mL (7.30 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.9200 mL	14.5998 mL	29.1996 mL
	5 mM	0.5840 mL	2.9200 mL	5.8399 mL
	10 mM	0.2920 mL	1.4600 mL	2.9200 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.