Physicochemical Properties
| Molecular Formula | C10H8N2S2 |
| Molecular Weight | 220.3 |
| Exact Mass | 220.012 |
| CAS # | 2127-03-9 |
| PubChem CID | 65093 |
| Appearance | White to off-white solid powder |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 356.1±17.0 °C at 760 mmHg |
| Melting Point | 56-58 °C(lit.) |
| Flash Point | 169.2±20.9 °C |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
| Index of Refraction | 1.694 |
| LogP | 2.53 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 3 |
| Heavy Atom Count | 14 |
| Complexity | 148 |
| Defined Atom Stereocenter Count | 0 |
| InChi Key | HAXFWIACAGNFHA-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C10H8N2S2/c1-3-7-11-9(5-1)13-14-10-6-2-4-8-12-10/h1-8H |
| Chemical Name | 2-(pyridin-2-yldisulfanyl)pyridine |
| Synonyms | OPSS2,2'-Dipyridyl disulfide Aldrithiol 2 Orthopyridyl disulfide |
| HS Tariff Code | 2934.99.9001 |
| Storage |
Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition | Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs) |
Biological Activity
| ln Vitro | Intramolecular S-S bond formation can be greatly accelerated by adding 2,2'-dipyridyl disulfide (2-PDS) solution to a mixture of air-oxidized cysteine-containing peptides [1]. |
| References |
[1]. 2,2'-Bispyridyl disulfide rapidly induces intramolecular disulfide bonds in peptides. Peptides. 1999;20(7):881-4. |
| Additional Infomation |
Aldrithiol is a member of the class of pyridines that is pyridine which is substituted by a pyridin-2-yldisulfanediyl group at position 2. It is a reagent used in molecular biology as an oxidizing agent. Also used in peptide synthesis and for detecting thiols. It has a role as an oxidising agent. It is an organic disulfide and a member of pyridines. 2,2'-Dithiodipyridine has been reported in Marsypopetalum modestum and Allium stipitatum with data available. |
Solubility Data
| Solubility (In Vitro) | DMSO : ~100 mg/mL (~453.91 mM) |
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (11.35 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (11.35 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 2.5 mg/mL (11.35 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.5393 mL | 22.6963 mL | 45.3926 mL | |
| 5 mM | 0.9079 mL | 4.5393 mL | 9.0785 mL | |
| 10 mM | 0.4539 mL | 2.2696 mL | 4.5393 mL |