(±)2-(14,15-Epoxyeicosatrienoyl) glycerol ((±)2-14,15-EG) is a novel CYP450 metabolite of 2-Arachidonoyl glycerol (2-AG) in the kidney. 7 (±)2-14,15-EG is a potent mitogen in renal epithelial cells and increases DNA synthesis in LLCPKcl4 cells. (±)2-(14,15-Epoxyeicosatrienoyl) glycerol activates the metalloproteinase ADAM17, thereby initiating the EGFR-ERK signaling pathway.

Physicochemical Properties

Molecular Formula	C23H38O5
Molecular Weight	394.54
CAS #	848667-56-1
SMILES	CCCCCC1C(C/C=C\C/C=C\C/C=C\CCCC(=O)OC(CO)CO)O1
Synonyms	(±)2-14,15-EG
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Mitogenic activity and signaling mechanism of 2-(14,15- epoxyeicosatrienoyl)glycerol, a novel cytochrome p450 arachidonate metabolite. Mol Cell Biol. 2007 Apr;27(8):3023-34.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.5346 mL	12.6730 mL	25.3460 mL
	5 mM	0.5069 mL	2.5346 mL	5.0692 mL
	10 mM	0.2535 mL	1.2673 mL	2.5346 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.