2'-Deoxyguanosine 5'-monophosphate disodium (5'-dGMP disodium) is a mononucleotide with guanine as the nucleobase. 2'-Deoxyguanosine 5'-monophosphate disodium is an analogue of the nucleic acid guanosine triphosphate (GTP).

Physicochemical Properties

Molecular Formula	C10H12N5NA2O7P
Molecular Weight	391.18
Exact Mass	391.026
CAS #	33430-61-4
Related CAS #	2'-Deoxyguanosine 5'-monophosphate-13C10,15N5 disodium
PubChem CID	135742695
Appearance	White to off-white solid powder
Density	2.32g/cm3
Boiling Point	844.2ºC at 760mmHg
Melting Point	>245°C (dec.)
Flash Point	464.4ºC
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	3
Heavy Atom Count	25
Complexity	556
Defined Atom Stereocenter Count	3
SMILES	C1[C@@H]([C@H](O[C@H]1N2C=NC3=C2N=C(NC3=O)N)COP(=O)([O-])[O-])O.[Na+].[Na+]
InChi Key	CTPAMSRBXKGZCJ-FVALZTRZSA-L
InChi Code	InChI=1S/C10H14N5O7P.2Na/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20;;/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17);;/q;2*+1/p-2/t4-,5+,6+;;/m0../s1
Chemical Name	disodium;[(2R,3S,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methyl phosphate
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. The photosensitizing activity of lumazine using 2'-deoxyguanosine 5'-monophosphate and HeLa cells as targets. Photochem Photobiol Sci. 2009 Nov;8(11):1539-49.

Solubility Data

Solubility (In Vitro)	H2O :~125 mg/mL (~319.55 mM) DMSO :< 1 mg/mL
Solubility (In Vivo)	Solubility in Formulation 1: 100 mg/mL (255.64 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.5564 mL	12.7818 mL	25.5637 mL
	5 mM	0.5113 mL	2.5564 mL	5.1127 mL
	10 mM	0.2556 mL	1.2782 mL	2.5564 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.