2'-Deoxyadenosine-5'-triphosphate trisodium (dATP trisodium) is a nucleotide used in cells for DNA synthesis or replication. 2'-Deoxyadenosine-5'-triphosphate (dATP) is a substrate for DNA polymerase.

Physicochemical Properties

Molecular Formula	C10H16N5NA3O12P3
Molecular Weight	560.150937080383
Exact Mass	513.99
CAS #	54680-12-5
Related CAS #	2'-Deoxyadenosine-5'-triphosphate;1927-31-7
PubChem CID	156592467
Appearance	White to off-white solid powder
Hydrogen Bond Donor Count	6
Hydrogen Bond Acceptor Count	16
Rotatable Bond Count	8
Heavy Atom Count	31
Complexity	769
Defined Atom Stereocenter Count	3
SMILES	P(=O)(O)(OP(=O)(O)OP(=O)(O)O)OC[C@@H]1[C@H](C[C@H](N2C=NC3C(N)=NC=NC2=3)O1)O.[Na].[Na].[Na]
InChi Key	CTWSMCPXFWEUIY-VWZUFWLJSA-N
InChi Code	InChI=1S/C10H16N5O12P3.Na/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(25-7)2-24-29(20,21)27-30(22,23)26-28(17,18)19;/h3-7,16H,1-2H2,(H,20,21)(H,22,23)(H2,11,12,13)(H2,17,18,19);/t5-,6+,7+;/m0./s1
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	Human Endogenous Metabolite
References	[1]. P J Romaniuk, A study of the mechanism of T4 DNA polymerase with diastereomeric phosphorothioate analogues of deoxyadenosine triphosphate. J Biol Chem. 1982 Jul 10;257(13):7684-8.

Solubility Data

Solubility (In Vitro)	H2O : 250 mg/mL (448.73 mM) DMSO : 4.55 mg/mL (8.17 mM)
Solubility (In Vivo)	Solubility in Formulation 1: 100 mg/mL (179.49 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.7852 mL	8.9262 mL	17.8524 mL
	5 mM	0.3570 mL	1.7852 mL	3.5705 mL
	10 mM	0.1785 mL	0.8926 mL	1.7852 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.