12(S)-HETrE is a fatty acid metabolite that inhibits platelet aggregation. 12(S)-HETrE can be used in thrombosis-related research.

Physicochemical Properties

Molecular Formula	C20H34O3
Molecular Weight	322.48
CAS #	72710-10-2
SMILES	O[C@H](/C=C/C=C\CCCCCCC(=O)O)C/C=C\CCCCC
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	Platelet Aggregation[1]
ln Vitro	12(S)-HPETrE (200 μM) significantly inhibited thrombin-induced thrombus retraction in the presence or absence of aspirin [1]. 12(S)-HETrE inhibits platelet aggregation with an IC50 value of 5 μM[1].
References	[1]. Investigations of human platelet-type 12-lipoxygenase: role of lipoxygenase products in platelet activation. J Lipid Res. 2012 Dec;53(12):2546-59.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.1010 mL	15.5048 mL	31.0097 mL
	5 mM	0.6202 mL	3.1010 mL	6.2019 mL
	10 mM	0.3101 mL	1.5505 mL	3.1010 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.