Physicochemical Properties
| Molecular Formula | C12H24O3 |
| Molecular Weight | 216.32 |
| Exact Mass | 216.173 |
| CAS # | 505-95-3 |
| Related CAS # | 27925-01-5 |
| PubChem CID | 79034 |
| Appearance | White to off-white solid powder |
| Density | 0.988g/cm3 |
| Boiling Point | 359.2ºC at 760 mmHg |
| Melting Point | 85-88ºC(lit.) |
| Flash Point | 185.2ºC |
| Index of Refraction | 1.467 |
| LogP | 2.964 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 11 |
| Heavy Atom Count | 15 |
| Complexity | 146 |
| Defined Atom Stereocenter Count | 0 |
| InChi Key | ZDHCZVWCTKTBRY-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C12H24O3/c13-11-9-7-5-3-1-2-4-6-8-10-12(14)15/h13H,1-11H2,(H,14,15) |
| Chemical Name | 12-hydroxydodecanoic acid |
| HS Tariff Code | 2934.99.9001 |
| Storage |
Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition | Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs) |
Biological Activity
| ADME/Pharmacokinetics |
Metabolism / Metabolites 12-Hydroxylauric acid is a known human metabolite of lauric acid. |
| Additional Infomation |
12-hydroxylauric acid is a medium-chain fatty acid that is the 12-hydroxylated derivative of lauric acid. It has a role as a human metabolite. It is functionally related to a dodecanoic acid. It is a conjugate acid of a 12-hydroxylaurate. 12-Hydroxydodecanoic acid has been reported in Trypanosoma brucei and Pinus radiata with data available. |
Solubility Data
| Solubility (In Vitro) | DMSO: 100 mg/mL (462.28 mM) |
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (11.56 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (11.56 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.6228 mL | 23.1139 mL | 46.2278 mL | |
| 5 mM | 0.9246 mL | 4.6228 mL | 9.2456 mL | |
| 10 mM | 0.4623 mL | 2.3114 mL | 4.6228 mL |