1-O-Hexadecylglycerol can upregulate the expression of PPAR-γ, inhibit pGE2, and exhibit anti-inflammatory properties. 1-O-Hexadecylglycerol is effective when taken orally.

Physicochemical Properties

Molecular Formula	C19H40O3
Molecular Weight	316.53
Exact Mass	316.298
CAS #	6145-69-3
PubChem CID	72733
Appearance	Solid powder
Melting Point	60-65ºC
LogP	4.837
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	18
Heavy Atom Count	22
Complexity	197
Defined Atom Stereocenter Count	0
SMILES	CCCCCCCCCCCCCCCCOCC(CO)O
InChi Key	OOWQBDFWEXAXPB-UHFFFAOYSA-N
InChi Code	InChI=1S/C19H40O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-22-18-19(21)17-20/h19-21H,2-18H2,1H3
Chemical Name	3-hexadecoxypropane-1,2-diol
Synonyms	1-O-HDG; HXDG
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	PPAR-γ
References	[1]. Chimyl Alcohol Suppresses PGE2 Synthesis by Human Epidermal Keratinocytes through the Activation of PPAR-γ. J Oleo Sci. 2018 Apr 1;67(4):455-462. [2]. Absorption of chimyl alcohol in man. Proc Soc Exp Biol Med. 1959 Apr;100(4):802-5.
Additional Infomation	1-O-palmitylglycerol is an alkylglycerol that is glycerol carrying a single palmityl (hexadecyl) substituent at position 1. Chimyl alcohol has been reported in Lobophytum and Doris montereyensis with data available.

Solubility Data

Solubility (In Vitro)	DMSO : 200 mg/mL (631.85 mM; with sonication)
Solubility (In Vivo)	Solubility in Formulation 1: ≥ 5 mg/mL (15.80 mM)(Saturation unknown) in 10% DMSO 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution, add 100 μL of 50.0 mg/mL clear DMSO stock solution to 900 μL corn oil and mix well.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.1593 mL	15.7963 mL	31.5926 mL
	5 mM	0.6319 mL	3.1593 mL	6.3185 mL
	10 mM	0.3159 mL	1.5796 mL	3.1593 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.