1-Methylhistamine diHCl is a histamine metabolite.

Physicochemical Properties

Molecular Formula	C6H13CL2N3
Molecular Weight	198.09
Exact Mass	161.072
CAS #	6481-48-7
Related CAS #	1-Methylhistamine-d3 dihydrochloride;344299-49-6;1-Methylhistamine;501-75-7
PubChem CID	11957601
Appearance	Off-white to gray solid powder
LogP	1.423
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	2
Heavy Atom Count	11
Complexity	84.4
Defined Atom Stereocenter Count	0
InChi Key	AGXVEALMQHTMSW-UHFFFAOYSA-N
InChi Code	InChI=1S/C6H11N3.2ClH/c1-9-4-6(2-3-7)8-5-9;;/h4-5H,2-3,7H2,1H3;2*1H
Chemical Name	2-(1-methylimidazol-4-yl)ethanamine;dihydrochloride
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	Human Endogenous Metabolite
ln Vitro	1-Methylhistamine dihydrochloride is the end result of histamine 1-methyltransferase in the metabolic pathway responsible for histidine [1].
References	[1]. Determination of urinary excretion of histamine and 1-methylhistamine by liquid chromatography. J Chromatogr B Biomed Appl. 1994 Apr 1;654(2):270-5.

Solubility Data

Solubility (In Vitro)	H2O :~62.5 mg/mL (~315.51 mM)
Solubility (In Vivo)	Solubility in Formulation 1: 100 mg/mL (504.82 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	5.0482 mL	25.2411 mL	50.4821 mL
	5 mM	1.0096 mL	5.0482 mL	10.0964 mL
	10 mM	0.5048 mL	2.5241 mL	5.0482 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.