Physicochemical Properties
| Molecular Formula | C3H9NO |
| Molecular Weight | 75.1097 |
| Exact Mass | 75.068 |
| CAS # | 78-96-6 |
| PubChem CID | 4 |
| Appearance | Colorless to light green liquid |
| Density | 0.9±0.1 g/cm3 |
| Boiling Point | 159.9±13.0 °C at 760 mmHg |
| Melting Point | -2ºC |
| Flash Point | 73.9±0.0 °C |
| Vapour Pressure | 0.9±0.6 mmHg at 25°C |
| Index of Refraction | 1.440 |
| LogP | -0.96 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 1 |
| Heavy Atom Count | 5 |
| Complexity | 22.9 |
| Defined Atom Stereocenter Count | 0 |
| SMILES | OC(CN)C |
| InChi Key | HXKKHQJGJAFBHI-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C3H9NO/c1-3(5)2-4/h3,5H,2,4H2,1H3 |
| Chemical Name | 1-aminopropan-2-ol |
| HS Tariff Code | 2934.99.9001 |
| Storage |
Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition | Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs) |
Biological Activity
| Toxicity/Toxicokinetics |
Non-Human Toxicity Values LD50 Rat oral 4.26 g/kg |
| References |
[1]. 1-Aminopropan-2-ol is a microbial metabolism of amino alcohol metabolism via propionaldehyde and acetaldehyde in a species of Pseudomonas[1]. |
| Additional Infomation |
Monoisopropanolamine appears as a colorless liquid with a slight ammonia-like odor. Less dense than water and soluble in water. Flash point 165 °F. Corrosive to metals and tissue. Vapors are heavier than air. Produces toxic oxides of nitrogen during combustion. Used in plastics, paints, cutting oils, and specialized cleaning compounds. 1-aminopropan-2-ol is any amino alcohol that is propan-2-ol substituted by an amino group at position 1. It has a role as an Escherichia coli metabolite. It is an amino alcohol and a secondary alcohol. 1-Amino-2-propanol is a metabolite found in or produced by Escherichia coli (strain K12, MG1655). 1-Aminopropan-2-ol has been reported in Antennaria plantaginifolia, Homo sapiens, and other organisms with data available. |
Solubility Data
| Solubility (In Vitro) | DMSO : ~250 mg/mL (~3328.45 mM) |
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (27.69 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (27.69 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 2.08 mg/mL (27.69 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 13.3138 mL | 66.5690 mL | 133.1381 mL | |
| 5 mM | 2.6628 mL | 13.3138 mL | 26.6276 mL | |
| 10 mM | 1.3314 mL | 6.6569 mL | 13.3138 mL |