1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a synthetic phospholipid used in liposomes and lipid bilayers. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine is used to study lipid monolayers and bilayers.

Physicochemical Properties

Molecular Formula	C36H72NO8P
Molecular Weight	677.93
Exact Mass	677.499
CAS #	18194-24-6
Related CAS #	1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d58;326495-29-8;1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d4;185906-01-8;1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d9;71479-88-4;1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d13;326495-28-7;1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d63;326495-30-1;1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d67;326495-32-3;(Rac)-1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d72;100483-63-4
PubChem CID	5459377
Appearance	White to off-white solid powder
Boiling Point	> 300ºC
Melting Point	130ºC to 139ºC
LogP	8.75
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	36
Heavy Atom Count	46
Complexity	765
Defined Atom Stereocenter Count	1
SMILES	CCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)([O-])OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCC
InChi Key	CITHEXJVPOWHKC-UUWRZZSWSA-N
InChi Code	InChI=1S/C36H72NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-35(38)42-32-34(33-44-46(40,41)43-31-30-37(3,4)5)45-36(39)29-27-25-23-21-19-17-15-13-11-9-7-2/h34H,6-33H2,1-5H3/t34-/m1/s1
Chemical Name	[(2R)-2,3-di(tetradecanoyloxy)propyl] 2-(trimethylazaniumyl)ethyl phosphate
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Effect of polyols on the DMPC lipid monolayers and bilayers. Biochim Biophys Acta Biomembr. 2018 Nov;1860(11):2166-2174.

Additional Infomation

1,2-di-O-myristoyl-sn-glycero-3-phosphocholine is a 1,2-diacyl-sn-glycero-3-phosphocholine where the two phosphatidyl acyl groups are specified as tetradecanoyl (myristoyl). It has a role as an antigen and a mouse metabolite. It is a 1,2-diacyl-sn-glycero-3-phosphocholine, a phosphatidylcholine 28:0 and a tetradecanoate ester. Dimyristoyl Lecithin is a myristoylated phosphatidylcholine, and a synthetic phospholipid used in liposomes and lipid bilayers with drug delivery property. A synthetic phospholipid used in liposomes and lipid bilayers for the study of biological membranes. See also: Dimyristoylphosphatidylcholine (annotation moved to).

Solubility Data

Solubility (In Vitro)

Ethanol: 50 mg/mL (73.75 mM) DMSO: < 1 mg/mL

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 5 mg/mL (7.38 mM) (saturation unknown) in 10% EtOH + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 50.0 mg/mL clear EtOH stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 5 mg/mL (7.38 mM) (saturation unknown) in 10% EtOH + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 50.0 mg/mL clear EtOH stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 5 mg/mL (7.38 mM) (saturation unknown) in 10% EtOH + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 50.0 mg/mL clear EtOH stock solution to 900 μL of corn oil and mix well.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.4751 mL	7.3754 mL	14.7508 mL
	5 mM	0.2950 mL	1.4751 mL	2.9502 mL
	10 mM	0.1475 mL	0.7375 mL	1.4751 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.