1,1'-(Azodicarbonyl)-dipiperidine (ADDP) can be used for the condensation reaction of alcohols with acidic compounds. 1,1'-(Azodicarbonyl)-dipiperidine can also be used to synthesize GPR120 agonists with anti-diabetic activity, as well as to synthesize triple agonists of PPARα, PPARγ, and PPARδ. 1,1'-(Azodicarbonyl)-dipiperidine can be used for the study of metabolic diseases.

Physicochemical Properties

Molecular Formula	C12H20N4O2
Molecular Weight	252.31
CAS #	10465-81-3
Appearance	Solid powder
SMILES	O=C(N=NC(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
Synonyms	Azodicarbonyl dipiperidine; ADDP; SR 4077
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets

PPARα PPAR-γ PPARδ

References

[1]. 1, 1′-(azodicarbonyl) dipiperidine-tributylphosphine, a new reagent system for mitsunobu reactionJ. Tetrahedron letters, 1993, 34(10): 1639-1642. [2]. Systematic Evaluation of 2-Arylazocarboxylates and 2-Arylazocarboxamides as Mitsunobu Reagents. J Org Chem. 2018 Apr 20;83(8):4712-4729. [3]. Design, synthesis and SAR of a novel series of heterocyclic phenylpropanoic acids as GPR120 agonists. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3272-3278. [4]. Design and synthesis of novel PPARalpha/gamma/delta triple activators using a known PPARalpha/gamma dual activator as structural template. Bioorg Med Chem Lett. 2003 Jan 20;13(2):257-60.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.9634 mL	19.8169 mL	39.6338 mL
	5 mM	0.7927 mL	3.9634 mL	7.9268 mL
	10 mM	0.3963 mL	1.9817 mL	3.9634 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.