(S)-3-(4-Hydroxyphenyl)-2-hydroxypropionic acid (compound 1) is a metabolite extracted from the culture medium of Leuconostoc mesenteroides. (S)-3-(4-Hydroxyphenyl)-2-hydroxypropionic acid has high DPPH free radical scavenging activity and anti-oxidant effect.

Physicochemical Properties

Molecular Formula	C9H10O4
Molecular Weight	182.17
Exact Mass	182.058
CAS #	23508-35-2
PubChem CID	9920545
Appearance	White to off-white solid powder
Density	1.404g/cm3
Boiling Point	414.4ºC at 760mmHg
Melting Point	165-168 °C
Flash Point	218.6ºC
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.617
LogP	0.38
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	3
Heavy Atom Count	13
Complexity	173
Defined Atom Stereocenter Count	1
SMILES	C1=CC(=CC=C1C[C@@H](C(=O)O)O)O
InChi Key	JVGVDSSUAVXRDY-QMMMGPOBSA-N
InChi Code	InChI=1S/C9H10O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8,10-11H,5H2,(H,12,13)/t8-/m0/s1
Chemical Name	(2S)-2-hydroxy-3-(4-hydroxyphenyl)propanoic acid
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References	[1]. Isolation and antioxidative activity of amino acid derivatives produced by Leuconostoc mesenteroides. Food Sci Biotechnol. 2016 Feb 29;25(1):329-334.
Additional Infomation	(2S)-2-Hydroxy-3-(4-hydroxyphenyl)propanoic acid has been reported in Grosmannia huntii with data available.

Solubility Data

Solubility (In Vitro)

DMSO: 100 mg/mL (548.94 mM）

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (13.72 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (13.72 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	5.4894 mL	27.4469 mL	54.8938 mL
	5 mM	1.0979 mL	5.4894 mL	10.9788 mL
	10 mM	0.5489 mL	2.7447 mL	5.4894 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.