(R,R)-(+)-Hydrobenzoin is an organic catalyst.

Physicochemical Properties

Molecular Formula	C₁₄H₁₄O₂
Molecular Weight	214.26
Exact Mass	214.099
CAS #	52340-78-0
PubChem CID	853019
Appearance	White to off-white solid powder
Density	1.193g/cm3
Boiling Point	373ºC at 760 mmHg
Melting Point	146-149ºC(lit.)
Flash Point	179.8ºC
Index of Refraction	95 ° (C=1, CHCl3)
LogP	2.453
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	3
Heavy Atom Count	16
Complexity	171
Defined Atom Stereocenter Count	2
SMILES	C1=CC=C(C=C1)[C@H]([C@@H](C2=CC=CC=C2)O)O
InChi Key	IHPDTPWNFBQHEB-ZIAGYGMSSA-N
InChi Code	InChI=1S/C14H14O2/c15-13(11-7-3-1-4-8-11)14(16)12-9-5-2-6-10-12/h1-10,13-16H/t13-,14-/m1/s1
Chemical Name	(1R,2R)-1,2-diphenylethane-1,2-diol
Synonyms	(R,R)(+)Hydrobenzoin; (R,R) (+) Hydrobenzoin
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: (1). This product requires protection from light (avoid light exposure) during transportation and storage.(2). Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References	[1]. Synthesis of enantiopure cyclopentitols and aminocyclopentitols mediated by oxyselenenylation of cyclopentene with (R,R)-hydrobenzoin. Tetrahedron Letters. 1988. [2]. (+)-(1R,2R)-1,2-Diphenylethane-1,2-diol.
Additional Infomation	(R,R)-hydrobenzoin is a hydrobenzoin and an ethanediol derivative.

Solubility Data

Solubility (In Vitro)

DMSO : ~100 mg/mL (~466.72 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 4.55 mg/mL (21.24 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 45.5 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (11.67 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 2.5 mg/mL (11.67 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	4.6672 mL	23.3361 mL	46.6723 mL
	5 mM	0.9334 mL	4.6672 mL	9.3345 mL
	10 mM	0.4667 mL	2.3336 mL	4.6672 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.