(R)-Oxiracetam is the R-isomer of oxiracetam (also known as ISF 2522), which is a widely used nootropic drug and improves memory and learning in patients with cognitive impairments. Oxiracetam (50 mg/kg i.p.) improves avoidance acquisition in BALB/c mice. Oxiracetam (100 mg/kg i.p.) reduces the scopolamine-induced amnesic effect and decrease in acetylcholine level in the cortex and hippocampus. Oxiracetam pretreatment (30 mg/kg) prevents social recognition deficits produced with trimethyltin in rats.

Physicochemical Properties

Molecular Formula	C6H10N2O3
Molecular Weight	158.16
Exact Mass	158.069
CAS #	68252-28-8
Related CAS #	(S)-Oxiracetam;88929-35-5;Oxiracetam;62613-82-5
PubChem CID	3051965
Appearance	Typically exists as solid at room temperature
Density	1.4±0.1 g/cm3
Boiling Point	494.6±40.0 °C at 760 mmHg
Flash Point	252.9±27.3 °C
Vapour Pressure	0.0±2.9 mmHg at 25°C
Index of Refraction	1.570
LogP	-2.48
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	2
Heavy Atom Count	11
Complexity	192
Defined Atom Stereocenter Count	1
SMILES	O=C(N)CN1C(C[C@@H](O)C1)=O
InChi Key	IHLAQQPQKRMGSS-UHFFFAOYSA-N
InChi Code	InChI=1S/C6H10N2O3/c7-5(10)3-8-2-4(9)1-6(8)11/h4,9H,1-3H2,(H2,7,10)
Chemical Name	4-Hydroxy-2-oxopyrrolidine-N-acetamide
Synonyms	(R)-Oxiracetam; R-Oxiracetam; (R)-ISF-2522; ISF 2522;ISF2522;Oxiracetam; ISF-2522; Neuractiv; Hydroxypiracetam;
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vitro	In vitro activity: Oxiracetam (also known as ISF 2522), a cyclic derivative of gamma-aminobutyric acid (GABA), is used as a nootropic drug to improve memory and learning.
ln Vivo	Oxiracetam (50 mg/kg i.p.) improves avoidance acquisition in BALB/c mice. Oxiracetam (100 mg/kg i.p.) reduces the scopolamine-induced amnesic effect and decrease in acetylcholine level in the cortex and hippocampus. Oxiracetam pretreatment (30 mg/kg) prevents social recognition deficits produced with trimethyltin in rats.
Animal Protocol	50 mg/kg i.p. BALB/c mice
References	Arch Int Pharmacodyn Ther.1985 May;275(1):86-92;Pharmacol Biochem Behav.1987 Jul;27(3):491-5.

Solubility Data

Solubility (In Vitro)	DMSO:31 mg/mL (196.0 mM) Water:31 mg/mL (196.0 mM) Ethanol:<1 mg/mL
Solubility (In Vivo)	Solubility in Formulation 1: 100 mg/mL (632.27 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	6.3227 mL	31.6136 mL	63.2271 mL
	5 mM	1.2645 mL	6.3227 mL	12.6454 mL
	10 mM	0.6323 mL	3.1614 mL	6.3227 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.