(R)-ONO-2952 is the R-isomer of ONO-2952. ONO-2952 is a specific, orally bioactive TSPO antagonist (inhibitor) with Kis values of 0.330-9.30 nM for rat and human TSPO.

Physicochemical Properties

Molecular Formula	C22H20CLFN2O2
Molecular Weight	398.86
Related CAS #	ONO-2952;895169-20-7
Appearance	White to off-white solid powder
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Mitsui K, et al. Anti-stress effects of ONO-2952, a novel translocator protein 18 kDa antagonist, in rats. Neuropharmacology. 2015 Dec;99:51-66.

Solubility Data

Solubility (In Vitro)

DMSO :~220 mg/mL (~551.57 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 5.5 mg/mL (13.79 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 55.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.5071 mL	12.5357 mL	25.0715 mL
	5 mM	0.5014 mL	2.5071 mL	5.0143 mL
	10 mM	0.2507 mL	1.2536 mL	2.5071 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.