(R)-(-)-1,1'-Binaphthyl-2,2'-diyl Hydrogenphosphate is a biochemical compound that could be utilized as a biomaterial or organic/chemical reagent for biomedical research.

Physicochemical Properties

Molecular Formula	C20H13O4P
Molecular Weight	348.29
Exact Mass	348.055
CAS #	39648-67-4
PubChem CID	99589
Appearance	White to off-white solid powder
Density	1.5±0.1 g/cm3
Boiling Point	619.5±38.0 °C at 760 mmHg
Melting Point	>300ºC
Flash Point	328.5±26.8 °C
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.763
LogP	3.99
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	0
Heavy Atom Count	25
Complexity	508
Defined Atom Stereocenter Count	0
InChi Key	JEHUZVBIUCAMRZ-UHFFFAOYSA-N
InChi Code	InChI=1S/C20H13O4P/c21-25(22)23-17-11-9-13-5-1-3-7-15(13)19(17)20-16-8-4-2-6-14(16)10-12-18(20)24-25/h1-12H,(H,21,22)
Chemical Name	13-hydroxy-12,14-dioxa-13λ5-phosphapentacyclo[13.8.0.02,11.03,8.018,23]tricosa-1(15),2(11),3,5,7,9,16,18,20,22-decaene 13-oxide
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: (1). This product requires protection from light (avoid light exposure) during transportation and storage.(2). Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vitro

In hydrocarboxylation processes, chiral ligands such as (R)-(-)-1,1'-Binaphthyl-2,2'-diyl hydrogen phosphate are employed. participates in asymmetric dipolar cycloadditions of diazo compounds by forming complexes with rhodium. With the help of this chiral acid, numerous racial amines that had proven challenging to separate have been resolved. Relative to rhodium, palladium derivatives have been employed in dipolar cycloaddition processes and in asymmetric hydrocarboxylation reactions. For chiral enantioselective Mannich processes, employing Bronsted acid as the catalyst.

Solubility Data

Solubility (In Vitro)

DMSO: 100 mg/mL (287.12 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (7.18 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (7.18 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 2.5 mg/mL (7.18 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.8712 mL	14.3559 mL	28.7117 mL
	5 mM	0.5742 mL	2.8712 mL	5.7423 mL
	10 mM	0.2871 mL	1.4356 mL	2.8712 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.