(NH2)2bpy (4,4'-Diamino-2,2'-bipyridine) is an organic/chemical reagent extensively used as a catalyst and coordination reagent. It can form complexes with other metal ions or organic molecules and can play a catalytic role in certain organic synthesis reactions. In addition, the compound is extensively used in certain chemical analysis and detection methods, such as in bioanalysis and electrochemical analysis.

Physicochemical Properties

Molecular Formula	C10H10N4
Molecular Weight	186.21
Exact Mass	186.09
CAS #	18511-69-8
PubChem CID	191515
Appearance	Off-white to gray solid powder
Density	1.3±0.1 g/cm3
Boiling Point	521.0±50.0 °C at 760 mmHg
Flash Point	301.9±17.3 °C
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.687
LogP	-0.2
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	1
Heavy Atom Count	14
Complexity	165
Defined Atom Stereocenter Count	0
SMILES	N1C([H])=C([H])C(=C([H])C=1C1C([H])=C(C([H])=C([H])N=1)N([H])[H])N([H])[H]
InChi Key	WTHJTVKLMSJXEV-UHFFFAOYSA-N
InChi Code	InChI=1S/C10H10N4/c11-7-1-3-13-9(5-7)10-6-8(12)2-4-14-10/h1-6H,(H2,11,13)(H2,12,14)
Chemical Name	2-(4-aminopyridin-2-yl)pyridin-4-amine
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: (1). This product requires protection from light (avoid light exposure) during transportation and storage.(2). Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vitro

For life science-related study, (NH2)2bpy is a biochemical reagent that can be utilized as an organic substance or biological material.

Solubility Data

Solubility (In Vitro)

DMSO: 100 mg/mL (537.03 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (13.43 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (13.43 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	5.3703 mL	26.8514 mL	53.7028 mL
	5 mM	1.0741 mL	5.3703 mL	10.7406 mL
	10 mM	0.5370 mL	2.6851 mL	5.3703 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.