![[Met5]-Enkephalin, amide TFA (5-Methionine-enkephalin amide TFA) 2918768-28-0](/picture/img/[Met5]-Enkephalin, amide TFA (5-Methionine-enkephalin amide TFA) Chemical Structure.png)
Physicochemical Properties
| CAS # | 2918768-28-0 |
| Related CAS # | [Met5]-Enkephalin, amide;60117-17-1 |
| Appearance | White to off-white solid powder |
| HS Tariff Code | 2934.99.9001 |
| Storage |
Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition | Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs) |
Biological Activity
| Targets | δ Opioid Receptor/DOR |
| ln Vitro | [Met5]-Enkephalin dramatically lowers the total number of glial cells in culture at concentrations of 0.1 nM, 10 nM, and 1 μM [1]. Cats' pelvic nerve-induced distal colon contractions are inhibited by [Met5]-Enkephalin, amide, which works through delta-opioid receptors. [Met5]-enkephalin has an IC50 value of 2.2 nM and inhibits pelvic nerve-evoked contractions in a concentration-dependent and reversible manner. At a high dosage (3 nM), [Met5]enkephalin strongly suppresses neurogenic contractions, but exogenous acetylcholine-induced contractions are unaffected [2]. |
| References |
[1]. Glial growth is regulated by agonists selective for multiple opioid receptor types in vitro. J Neurosci Res. 1991 Aug;29(4):538-48. [2]. [Met5]enkephalin acts via delta-opioid receptors to inhibit pelvic nerve-evoked contractions of cat distal colon. Br J Pharmacol. 1987 Oct;92(2):291-8. |
Solubility Data
| Solubility (In Vitro) | H2O: 100 mg/mL (145.62 mM) |
| Solubility (In Vivo) |
Solubility in Formulation 1: 50 mg/mL (72.81 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication. (Please use freshly prepared in vivo formulations for optimal results.) |