(±)-Leucine-d10 is the deuterated form of (±)-Leucine. (±)-Leucine (DL-Leucine), an isomer of leucine, is a chemical bactericide and dietary additive. (±)-Leucine suppresses the growth of E. coli by 92.08%.

Physicochemical Properties

Molecular Formula	C6H3D10NO2
Molecular Weight	141.23
Exact Mass	141.157
CAS #	29909-01-1
Related CAS #	(±)-Leucine;328-39-2
PubChem CID	16213561
Appearance	White to off-white solid powder
Density	1.0±0.1 g/cm3
Boiling Point	225.8±23.0 °C at 760 mmHg
Melting Point	293-296ºC (subl.)(lit.)
Flash Point	90.3±22.6 °C
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.463
LogP	0.73
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Heavy Atom Count	9
Complexity	101
Defined Atom Stereocenter Count	0
SMILES	[2H]C([2H])([2H])C([2H])(C([2H])([2H])[2H])C([2H])([2H])C([2H])(C(=O)O)N
InChi Key	ROHFNLRQFUQHCH-SHJFKSRGSA-N
InChi Code	InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/i1D3,2D3,3D2,4D,5D
Chemical Name	2-amino-2,3,3,4,5,5,5-heptadeuterio-4-(trideuteriomethyl)pentanoic acid
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vitro	Drug compounds have included stable heavy isotopes of carbon, hydrogen, and other elements, mostly as quantitative tracers while the drugs were being developed. Because deuteration may have an effect on a drug's pharmacokinetics and metabolic properties, it is a cause for concern [1].
References	[1]. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Attractiveness of tobacco budworm females altered by oral chemosterilants and dietary additives. Journal of Chemical Ecology. 1977 Mar; 127-131.

Solubility Data

Solubility (In Vitro)	H2O : 12.5 mg/mL (88.51 mM)
Solubility (In Vivo)	Solubility in Formulation 1: 10 mg/mL (70.81 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	7.0806 mL	35.4032 mL	70.8065 mL
	5 mM	1.4161 mL	7.0806 mL	14.1613 mL
	10 mM	0.7081 mL	3.5403 mL	7.0806 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.