(E)-Osmundacetone is the isomer of Osmundacetone. Osmundacetone significantly reduces the phosphorylation of JNK, ERK, and p38 kinases as well as other MAPKs. In terms of oxidative stress, osmundacetone has neuroprotective properties[1].

Physicochemical Properties

Molecular Formula	C10H10O3
Molecular Weight	178.1846
Exact Mass	178.063
CAS #	123694-03-1
Related CAS #	Osmundacetone;37079-84-8
PubChem CID	9942292
Appearance	Light yellow to yellow solid
Density	1.264g/cm3
Boiling Point	382.5ºC at 760mmHg
Melting Point	173-175ºC
Flash Point	199.3ºC
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.637
LogP	1.7
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	2
Heavy Atom Count	13
Complexity	210
Defined Atom Stereocenter Count	0
SMILES	O([H])C1=C(C([H])=C([H])C(/C(/[H])=C(\[H])/C(C([H])([H])[H])=O)=C1[H])O[H]
InChi Key	YIFZKRGUGKLILR-NSCUHMNNSA-N
InChi Code	InChI=1S/C10H10O3/c1-7(11)2-3-8-4-5-9(12)10(13)6-8/h2-6,12-13H,1H3/b3-2+
Chemical Name	(E)-4-(3,4-dihydroxyphenyl)but-3-en-2-one
Synonyms	(E)-Osmundacetone
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References	[1]. Protective Effect of Osmundacetone against Neurological Cell Death Caused by Oxidative Glutamate Toxicity. Biomolecules.2021 Feb 22;11(2):328.
Additional Infomation	(E)-3,4-Dihydroxybenzylideneacetone has been reported in Peltigera dolichorrhiza, Phellinus igniarius, and Inonotus obliquus with data available.

Solubility Data

Solubility (In Vitro)

DMSO: ~100 mg/mL (~561.2 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (14.03 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 2.5 mg/mL (14.03 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	5.6123 mL	28.0615 mL	56.1230 mL
	5 mM	1.1225 mL	5.6123 mL	11.2246 mL
	10 mM	0.5612 mL	2.8062 mL	5.6123 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.