(E)-3-(4-Methoxyphenyl)acrylic acid (compound 3) can be extracted from Arachis hypogaea, Scrophularia buergeriana Miquel, Aquilegia vulgaris, Anigozanthos preissii, etc. (E)-3-(4-Methoxyphenyl)acrylic acid has significant hepatoprotective activity, anti-amnesia, enhanced cognitive activity, hypoglycemic and neuro-protection activity.

Physicochemical Properties

Molecular Formula	C10H10O3
Molecular Weight	178.18
Exact Mass	178.062
CAS #	943-89-5
Related CAS #	7340-42-3 (hydrochloride salt)
PubChem CID	699414
Appearance	White to off-white solid powder
Density	1.2±0.1 g/cm3
Boiling Point	342.6±17.0 °C at 760 mmHg
Melting Point	173.5ºC
Flash Point	138.6±14.4 °C
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.591
LogP	2.36
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Heavy Atom Count	13
Complexity	190
Defined Atom Stereocenter Count	0
SMILES	COC1=CC=C(C=C1)/C=C/C(=O)O
InChi Key	AFDXODALSZRGIH-QPJJXVBHSA-N
InChi Code	InChI=1S/C10H10O3/c1-13-9-5-2-8(3-6-9)4-7-10(11)12/h2-7H,1H3,(H,11,12)/b7-4+
Chemical Name	(E)-3-(4-methoxyphenyl)prop-2-enoic acid
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References	[1]. Uncommon secondary metabolites from Etlingera pavieana rhizomes. Nat Prod Res. 2016 Oct;30(19):2215-9.
Additional Infomation	4-methoxycinnamic acid is a methoxycinnamic acid having a single methoxy substituent at the 4-position on the phenyl ring. It is functionally related to a cinnamic acid. 4-Methoxycinnamic acid has been reported in Baccharis subdentata, Scrophularia buergeriana, and other organisms with data available. See also: 4-Methoxycinnamic acid (annotation moved to).

Solubility Data

Solubility (In Vitro)

DMSO: 100 mg/mL (561.23 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (14.03 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (14.03 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 2.5 mg/mL (14.03 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	5.6123 mL	28.0615 mL	56.1230 mL
	5 mM	1.1225 mL	5.6123 mL	11.2246 mL
	10 mM	0.5612 mL	2.8062 mL	5.6123 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.