| Description | Zoxazolamine (NSC-24995) is a uricosuric and muscle relaxant. Zoxazolamine acts centrally as a muscle relaxant, but the mechanism of its action is not understood. |
| In vivo | Zoxazolamine是具有生物活性的2-氨基-2-恶唑类化合物。研究显示,Zoxazolamine是通过降低中枢神经元间活性发挥其中枢性肌肉松弛剂类药物的功能。这类药物不是抗焦虑药,降低多巴胺能的转化率,并在多巴胺能神经元中诱发一种类似pacemaker的放电模式。 Zoxazolamine也可用于评估肝细胞色素P-450活性。 |
| Synonyms | NSC 24995, Contrazole, 氯苯恶唑胺, 苯并恶唑胺 |
| molecular weight | 168.58 |
| Molecular formula | C7H5ClN2O |
| CAS | 61-80-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 32 mg/mL (189.8 mM) Ethanol: 32 mg/mL (189.8 mM) H2O: < 1 mg/mL (insoluble or slightly soluble) |
| References | 1. McMillen BA, et al. J Neural Transm Gen Sect, 1992, 89(1-2), 11-25. 2. Decken A, et al. J Inorg Biochem. 2005 Feb;99(2):664-7. |