| Description | ZINC77292789 (Fmoc-Thr[GalNAc(Ac)3-α-D]-OH) is a reagent for the preparation of a synthetic MUC1 Glycopeptide Bearing βGalNAc-Thr as a Tn antigen isomer which induces the antibody production against tumor cells. ZINC77292789 is a starting material to make trimeric MUC1 immunodominant motif antigen-based anti-cancer vaccine candidates. |
| In vitro | Tn 抗原是一种与肿瘤关联的碳水化合物抗原，在正常的外周组织或血细胞中不被表达。这种抗原在所有类型的人类癌症中大多数情况下被发现，其表达源于正常的O-糖基化途径中的阻塞，该途径中聚糖从共同前体GalNAcα1-O-Ser/Thr（Tn 抗原）[1]延伸。 |
| Synonyms | Fmoc-Thr[GalNAc(Ac)3-α-D]-OH, Fmoc-Thr(Ac₃AcNH-α-Gal)-OH |
| molecular weight | 670.66 |
| Molecular formula | C33H38N2O13 |
| CAS | 116783-35-8 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | H2O: soluble |
| References | 1. Ju T, et al. The Cosmc connection to the Tn antigen in cancer. Cancer Biomark. 2014 Jan 1;14(1):63-81. |