| Description | Zinc pyrithione (OM-1563), an antibacterial and antifungal agent can disrupt membrane transport by blocking the proton pump. |
| In vitro | 在暴露的贻贝组织中,Zinc pyrithione迅速积累,该过程与暴露浓度和时间成比例.尽管在相对较高的Zinc pyrithione环境中,7-d半数致死浓度(LC50)为8.27 μM,但这也表明Zinc pyrithione可能对沿海环境和海洋生物存在威胁,需要对其生物效应中亚致死量做进一步调查. |
| In vivo | 作为特异的合成增效剂,Zinc pyrithione通过诱导静息电位激活同种和异种的M通道。Zinc pyrithione被认为是一种锌配合物。Pyrithione配体（形式上的单阴离子）通过氧气和铁硫中心与Zn2+螯合。在晶体状态下,Zinc pyrithione以中心对称的二聚体存在,每个锌与两个硫和三个氧中心结合。但在溶液中, 二聚物通过锌氧键的断裂而解离。尽管Zinc pyrithione是一个二聚物,但其引起细胞质膜去极化的活性可能来自单体,,半数最大效应(K1/2)约为0.3 mM。 |
| Synonyms | 吡硫锌, OM-1563, 吡啶硫酮锌 |
| molecular weight | 317.71 |
| Molecular formula | C10H8N2O2S2Zn |
| CAS | 13463-41-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Ethanol: < 1 mg/mL (insoluble or slightly soluble) DMSO: 20 mg/mL (62.95 mM), Sonication is recommended. |
| References | 1. Ermolayeva E, et al. Appl Environ Microbiol, 1995, 61(9), 3385-3390. 2. Xiong Q, et al. Nat Chem Biol, 2007, 3(5), 287-296. 3. Marcheselli M, et al. Environ Toxicol Chem, 2010, 29(11), 2583-2592. |