| Description | ZIM, a norbornene derivative of 4-Aminoantipyrine, effectively induces DNA damage, leading to genomic and chromosomal alterations, cell death, and phagocytosis activation. Its properties highlight its potential as a chemotherapeutic agent in cancer research. |
| In vivo | ZIM (i.p., 12, 24, 和 48 mg/kg) 在成年雄性瑞士小鼠中有效降低染色体微核频率，各剂量均观察到化学预防效应，分别在24和72小时后显现，损伤减少百分比范围为38.36%至83.26%。[1] 此外，ZIM (i.p., 12, 24, 和 48 mg/kg) 也降低了由顺铂-CIS 和多柔比星-DOX 引发的肝细胞和肾细胞死亡频率。在 CIS 组中，12, 24, 和 48 mg/kg 浓度的肝损伤减少百分比分别为79.27%, 75.20%, 和 52.84%，而在 DOX 组中，分别为62.06%, 59.44%, 和 77.80%。CIS 组的肾损伤减少百分比分别为45.29%, 36.09%, 和 41.61%，DOX 组则分别为28.00%, 21.41%, 和 30.82%。[1] |
| molecular weight | 349.38 |
| Molecular formula | C20H19N3O3 |
| CAS | 301298-87-3 |
| Storage | |Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 10 mg/mL (28.62 mM), Sonication is recommended. |
| References | 1. Oliveira RJ, et al. ZIM, a Norbornene Derived from 4-Aminoantipyrine, Induces DNA Damage and Cell Death but in Association Reduces the Effect of Commercial Chemotherapeutics. Chem Res Toxicol. 2023;36(1):66-82. 2. Shikata M, et al. Characterization of Arabidopsis ZIM, a member of a novel plant-specific GATA factor gene family. J Exp Bot. 2004;55(397):631-639. 3. Chung HS, et al. A critical role for the TIFY motif in repression of jasmonate signaling by a stabilized splice variant of the JASMONATE ZIM-domain protein JAZ10 in Arabidopsis. Plant Cell. 2009;21(1):131-145. |