| Description | Zanapezil is an acetylcholinesterase (AChE) inhibitor. Zanapezil increases choline acetyltransferase activity in cultured rat septal cholinergic neurons. |
| Synonyms | TAK 147, TAK147, TAK-147 |
| molecular weight | 492.61 |
| Molecular formula | C29H36N2O5 |
| CAS | 263248-42-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Hatip-Al-Khatib I, Iwasaki K, Yoshimitsu Y, Arai T, Egashira N, Mishima K, Ikeda T, Fujiwara M. Effect of oral administration of zanapezil (TAK-147) for 21 days on acetylcholine and monoamines levels in the ventral hippocampus of freely moving rats. Br J Pharmacol. 2005 Aug;145(8):1035-44. PubMed PMID: 15951830; PubMed Central PMCID: PMC1576235. 2. Zhang LS, Jin CL, Li Q, Sun YC, Chen Z. [Influence of chronic epilepsy on spatial memory retrieval in rats]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2004 May;33(3):205-8. Chinese. PubMed PMID: 15179678. 3. Hatip-Al-Khatib I, Takashi A, Egashira N, Iwasaki K, Fujiwara M. Comparison of the effect of TAK-147 (zanapezil) and E-2020 (donepezil) on extracellular acetylcholine level and blood flow in the ventral hippocampus of freely moving rats. Brain Res. 2004 Jun 25;1012(1-2):169-76. PubMed PMID: 15158174. 4. Rakonczay Z. Potencies and selectivities of inhibitors of acetylcholinesterase and its molecular forms in normal and Alzheimer's disease brain. Acta Biol Hung. 2003;54(2):183-9. PubMed PMID: 14535624. |