| Description | Zacopride is a selective agonist of inward rectifier potassium current (I K1) channel, inhibiting ventricular arrhythmias without affecting atrial arrhythmias. |
| Synonyms | Racemic zacopride |
| molecular weight | 309.79 |
| Molecular formula | C15H20ClN3O2 |
| CAS | 90182-92-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Liu CF, Liu QH, Liu EL, Zhai XW, Zhang L, Luo TE, Zhang WF, Feng QL, Cui XL, Zhao ZQ, Cao JM, Wu BW. Activation of IK1 channel by zacopride attenuates left ventricular remodeling in rats with myocardial infarction. J Cardiovasc Pharmacol. 2014 Oct;64(4):345-56. doi: 10.1097/FJC.0000000000000127. Retraction in: J Cardiovasc Pharmacol. 2015 Mar;65(3):296. PubMed PMID: 25286360. 2. Zhang L, Liu Q, Liu C, Zhai X, Feng Q, Xu R, Cui X, Zhao Z, Cao J, Wu B. Zacopride selectively activates the Kir2.1 channel via a PKA signaling pathway in rat cardiomyocytes. Sci China Life Sci. 2013 Sep;56(9):788-96. doi: 10.1007/s11427-013-4531-z. Epub 2013 Aug 8. PubMed PMID: 23929001. 3. Bourdin CM, Lebreton J, Mathé-Allainmat M, Thany SH. Pharmacological profile of zacopride and new quaternarized fluorobenzamide analogues on mammalian α7 nicotinic acetylcholine receptor. Bioorg Med Chem Lett. 2015 Aug 15;25(16):3184-8. doi: 10.1016/j.bmcl.2015.05.094. Epub 2015 Jun 4. PubMed PMID: 26087938. 4. Curtis MJ. Activation of IK1 by zacopride: amelioration of left ventricular remodeling, but at what risk? J Cardiovasc Pharmacol. 2014 Oct;64(4):343-4. doi: 10.1097/FJC.0000000000000140. PubMed PMID: 25000479. |