| Description | (Z)-PUGNAc is a potent O-GlcNAcase inhibitor that is more active than (E)-PUGNAc, removes O-GlcNAc from proteins (peptide O-GlcNAc-β-N-acetylaminoglucosidase), and can be used to increase the levels of O-GlcNAc on nuclear and cytoplasmic proteins in vivo. |
| In vitro | 在HeLa和HEK细胞系统中，(Z)-PugNAc增强了蛋白质O-GlcNAc的掺入作用[1]。 |
| molecular weight | 353.33 |
| Molecular formula | C15H19N3O7 |
| CAS | 132489-69-1 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 10 mg/mL (28.30 mM), Sonication is recommended. |
| References | 1. Perreira M, et al. Inhibition of O-GlcNAcase by PUGNAc is dependent upon the oxime stereochemistry. Bioorg Med Chem. 2006;14(3):837-846. |