| Description | YM-53403 is an antiviral activity that effectively inhibits the replication of RSV strains belonging to subgroup A and subgroup B. It can be used to treat respiratory syncytial virus infections. |
| In vitro | YM-53403 (0.2 μM) 降低了斑块，其 EC50 为 0.20 ± 0.05 μM。[2] YM-53403 (50 μM) 在感染后约8小时抑制了 RSV 的生命周期，这表明其对 RSV 基因组的早期转录和/或复制具有抑制作用。由于 YM-53403 对 RSV 活性高效且作用方式新颖，它被视为治疗 RSV 感染的有吸引力的化合物。[2] |
| molecular weight | 583.7 |
| Molecular formula | C36H29N3O3S |
| CAS | 851331-05-0 |
| Storage | |Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 60 mg/mL (102.79 mM) |
| References | 1. Tiong Yip CL, et al. Characterization of a respiratory syncytial virus L protein inhibitor. Antimicrob Agents Chemother. 2014 Jul;58(7):3867-73. 2. Sudo K, et al. YM-53403, a unique anti-respiratory syncytial virus agent with a novel mechanism of action. Antiviral Res. 2005 Feb;65(2):125-31. 3. McCutcheon KM, et al. The Interferon Type I/III Response to Respiratory Syncytial Virus Infection in Airway Epithelial Cells Can Be Attenuated or Amplified by Antiviral Treatment. J Virol. 2015;90(4):1705-1717. |