| Description | YM-358 potassium hydrate is an orally active and long-lasting antagonist of angiotensin type 1 receptor. |
| Synonyms | YM-358, YM358, YM 358 |
| molecular weight | 455.587 |
| Molecular formula | C22H24KN8O |
| CAS | 161800-08-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Oka-Akagi T, Fujimori A, Shibasaki M, Matsuda-Satoh Y, Inagaki O, Yanagisawa I. Effects of angiotensin II type 1 receptor antagonist, YM358, on cardiac hypertrophy and dysfunction after myocardial infarction in rats. Biol Pharm Bull. 2002 Jul;25(7):857-60. PubMed PMID: 12132657. 2. Tokioka-Akagi T, Fujimori A, Shibasaki M, Inagaki O, Yanagisawa I. Comparison of the angiotensin II type 1-receptor antagonist YM358 and the angiotensin-converting enzyme inhibitor enalapril in rats with cardiac volume overload. Jpn J Pharmacol. 2001 May;86(1):79-85. PubMed PMID: 11430476. 3. Tokioka T, Shibasaki M, Fujimori A, Matsuda-Satoh Y, Uchida W, Inagaki O, Yanagisawa I. Effects of YM358, an angiotensin II type 1 (AT1) receptor antagonist, and enalapril on blood pressure and vasoconstriction in two renal hypertension models. Biol Pharm Bull. 2000 Feb;23(2):174-81. PubMed PMID: 10706380. 4. Sekine T, Kusano H, Nishimaru K, Tanaka Y, Tanaka H, Shigenobu K. Developmental conversion of inotropism by endothelin I and angiotensin II from positive to negative in mice. Eur J Pharmacol. 1999 Jun 25;374(3):411-5. PubMed PMID: 10422785. |