| Description | Y2 Antagonist 36 is a highly potent, soluble and selective antagonist of NPY Y2. |
| molecular weight | 493 |
| Molecular formula | C27H29ClN4O3 |
| CAS | 1185845-15-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Domingues MF, de Assis DR, Piovesan AR, Belo CAD, da Costa JC. Peptide YY (3-36) modulates intracellular calcium through activation of the phosphatidylinositol pathway in hippocampal neurons. Neuropeptides. 2017 Nov 7. pii: S0143-4179(16)30200-1. doi: 10.1016/j.npep.2017.11.003. [Epub ahead of print] PubMed PMID: 29157865. 2. Kojima SI, Kojima K, Fujita T. Investigation of 5-HT(3) receptor-triggered serotonin release from guinea-pig isolated colonic mucosa: a role of PYY-containing endocrine cell. Eur J Pharmacol. 2017 Mar 15;799:196-200. doi: 10.1016/j.ejphar.2017.02.011. Epub 2017 Feb 9. PubMed PMID: 28189582. 3. Hassan AM, Jain P, Mayerhofer R, Fröhlich EE, Farzi A, Reichmann F, Herzog H, Holzer P. Visceral hyperalgesia caused by peptide YY deletion and Y2 receptor antagonism. Sci Rep. 2017 Jan 20;7:40968. doi: 10.1038/srep40968. PubMed PMID: 28106168; PubMed Central PMCID: PMC5247702. 4. Alhadeff AL, Golub D, Hayes MR, Grill HJ. Peptide YY signaling in the lateral parabrachial nucleus increases food intake through the Y1 receptor. Am J Physiol Endocrinol Metab. 2015 Oct 15;309(8):E759-66. doi: 10.1152/ajpendo.00346.2015. Epub 2015 Sep 1. PubMed PMID: 26330345; PubMed Central PMCID: PMC4609877. |