| Description | Y-29794 Tosylate (Y-29794) is an orally active, effective, and specific non-peptide-prolyl endopeptidase (PPCE) inhibitor. |
| In vitro | Y-29794 Tosylate 能穿透大脑，展现出剂量依赖性和长效的抑制作用[2]。 |
| In vivo | Y-29794 Tosylate 以选择性及竞争性的方式可逆地抑制了大鼠脑中的PPCE[2]。研究发现，Y-29794 Tosylate 能增强TRH在大鼠海马区释放ACh的效果[2]。 |
| Synonyms | Y 29794, Y29794 tosylate, Y29794, Y-29794 |
| molecular weight | 590.86 |
| Molecular formula | C30H42N2O4S3 |
| CAS | 143984-17-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (84.62 mM) |
| References | 1. Kato A, Fukunari A, Sakai Y, Nakajima T. Prevention of amyloid-like deposition by a selective prolyl endopeptidase inhibitor, Y-29794, in senescence-accelerated mouse. J Pharmacol Exp Ther. 1997 Oct;283(1):328-35. PubMed PMID: 9336340. 2. Nakajima T, Ono Y, Kato A, Maeda J, Ohe T. Y-29794--a non-peptide prolyl endopeptidase inhibitor that can penetrate into the brain. Neurosci Lett. 1992 Jul 20;141(2):156-60. PubMed PMID: 1436628. |