| Description | Xanthohumol and xanthohumol D are potent inducers of quinone reductase, suggests that they could be used as chemoprevention agents. |
| In vitro | Six metabolites were obtained as a result of transformation of xanthohumol (1) by selected fungal cultures. Their structures were established on the basis of their spectral data. One of them: 2'-(2'''-hydroxyisopropyl)-dihydrofurano-[4',5':3',4']-4',2-dihydroxy-6'-methoxy-α±,β-dihydrochalcone (6) has not been previously reported in the literature. The antioxidant properties of hops flavonoids and Xanthohumol Derivatives were investigated using the 2,2'-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging method. The effects of these compounds on proliferation of MCF-7, PC-3 and HT-29 human cancer cell lines were determined by the SRB assay. |
| Target activity | QR2:110 μM (IC50) |
| Synonyms | 黄腐醇 D |
| molecular weight | 370.4 |
| Molecular formula | C21H22O6 |
| CAS | 274675-25-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| References | 1. Fungal metabolites of xanthohumol with potent antiproliferative activity on human cancer cell lines in vitro.Bioorg Med Chem. 2013 Apr 1;21(7):2001-6. |