| Description | Xanthine amine congener dihydrochloride (XAC dihydrochloride), a potent antagonist for both Adenosine A1 and A2 receptors, exhibits IC50 values of 1.8 nM for A1 and 114 nM for A2 receptors. Additionally, it functions as a convulsant agent in mouse models. |
| In vivo | Xanthine amine congener dihydrochloride is more potent as a convulsant than either caffeine or theophyllin in infusion studies at the dosage 39.8 mg/kg. XAC has no effects by administering the drug via an i.p. injection, the seizure threshold >1000 mg/kg[1]. Animal Model: Mice[1]Dosage: 39.8 mg/kg Administration: Infusion injection; single dose Result: Acted as a convulsant agent than either caffeine or theophyllin. |
| Target activity | A1 receptor:1.8 nM (IC50), A2 receptor:114 nM (IC50) |
| Synonyms | XAC dihydrochloride, Xanthine amine congener dihydrochloride |
| molecular weight | 501.41 |
| Molecular formula | C21H30Cl2N6O4 |
| CAS | 1962928-23-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. P F Morgan, et al.Potent Convulsant Actions of the Adenosine Receptor Antagonist, Xanthine Amine Congener (XAC). Life Sci. 1989;45(8):719-28 |
Xanthine amine congener dihydrochloride
CAS No.: 1962928-23-9
Xanthine amine congener dihydrochloride (XAC dihydrochloride), a potent antagonist for both Adenosine A1 and A2 receptor
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