| Description | X 910279 is a leflunomide analog and a malononitrilamide. |
| Synonyms | MNA-279, X91 0279, HMR 279, HMR 1279, MNA 279 |
| molecular weight | 253.26 |
| Molecular formula | C14H11N3O2 |
| CAS | 185915-32-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Schorlemmer HU, Bartlett RR, Schleyerbach R. Immunomodulatory activity of malononitrilamides, derivatives of leflunomide's primary metabolite, on models of experimental rheumatoid arthritis. Transplant Proc. 1998 Dec;30(8):4137-9. PubMed PMID: 9865326. 2. Schorlemmer HU, Kurrle R, Schleyerbach R, Bartlett RR. Disease-modifying activity of malononitrilamides, derivatives of leflunomide's active metabolite, on models of rheumatoid arthritis. Inflamm Res. 1999 Dec;48 Suppl 2:S113-4. PubMed PMID: 10667840. 3. Schorlemmer HU, Bartlett RR, Lindner JK, Kurrle R. Coadministration of malononitrilamides and tacrolimus induces tolerance in a rat skin allograft model. Transplant Proc. 1999 Feb-Mar;31(1-2):1184-8. PubMed PMID: 10083529. 4. Slauson SD, Silva HT, Sherwood SW, Morris RE. Flow cytometric analysis of the molecular mechanisms of immunosuppressive action of the active metabolite of leflunomide and its malononitrilamide analogues in a novel whole blood assay. Immunol Lett. 1999 Apr 15;67(3):179-83. PubMed PMID: 10369124. |