| Description | WNK-IN-12 is an effective, selective, and orally active WNK1 kinase inhibitor. |
| Synonyms | WNK inhibitor-12, WNKIN12, WNK IN 12, WNK inhibitor 12, WNK-IN-12 |
| molecular weight | 465.42 |
| Molecular formula | C21H18Cl2D3N5OS |
| CAS | 2123483-49-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| References | 1. Vorontsova I, Donaldson PJ, Kong Z, Wickremesinghe C, Lam L, Lim JC. The modulation of the phosphorylation status of NKCC1 in organ cultured bovine lenses: Implications for the regulation of fiber cell and overall lens volume. Exp Eye Res. 2017 Dec;165:164-174. doi: 10.1016/j.exer.2017.08.009. Epub 2017 Aug 14. PubMed PMID: 28818393. 2. AlAmri MA, Kadri H, Alderwick LJ, Simpkins NS, Mehellou Y. Rafoxanide and Closantel Inhibit SPAK and OSR1 Kinases by Binding to a Highly Conserved Allosteric Site on Their C-terminal Domains. ChemMedChem. 2017 May 9;12(9):639-645. doi: 10.1002/cmdc.201700077. Epub 2017 Apr 12. PubMed PMID: 28371477. 3. Zhang J, Deng X, Kahle KT. Leveraging unique structural characteristics of WNK kinases to achieve therapeutic inhibition. Sci Signal. 2016 Oct 18;9(450):pe3. Review. PubMed PMID: 27811182. 4. Bhuiyan MIH, Song S, Yuan H, Begum G, Kofler J, Kahle KT, Yang SS, Lin SH, Alper SL, Subramanya AR, Sun D. WNK-Cab39-NKCC1 signaling increases the susceptibility to ischemic brain damage in hypertensive rats. J Cereb Blood Flow Metab. 2017 Aug;37(8):2780-2794. doi: 10.1177/0271678X16675368. Epub 2016 Jan 1. PubMed PMID: 27798271; PubMed Central PMCID: PMC5536788. |