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VUF11211

CAS No.: 906556-51-2

VUF11211 is an effective antagonist of CXCR3 that acts by extending from the minor pocket into the major pocket of the t
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Description VUF11211 is an effective antagonist of CXCR3 that acts by extending from the minor pocket into the major pocket of the transmembrane domains.
Synonyms VUF-11211, VUF 11211
molecular weight 504.49
Molecular formula C26H35Cl2N5O
CAS 906556-51-2
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
References 1. Ganghammer S, Gutjahr J, Hutterer E, Krenn PW, Pucher S, Zelle-Rieser C, Jöhrer K, Wijtmans M, Leurs R, Smit MJ, Gattei V, Greil R, Hartmann TN. Combined CXCR3/CXCR4 measurements are of high prognostic value in chronic lymphocytic leukemia due to negative co-operativity of the receptors. Haematologica. 2016 Mar;101(3):e99-102. doi: 10.3324/haematol.2015.133470. Epub 2015 Nov 20. PubMed PMID: 26589908; PubMed Central PMCID: PMC4815737. 2. Scholten DJ, Wijtmans M, van Senten JR, Custers H, Stunnenberg A, de Esch IJ, Smit MJ, Leurs R. Pharmacological characterization of [3H]VUF11211, a novel radiolabeled small-molecule inverse agonist for the chemokine receptor CXCR3. Mol Pharmacol. 2015 Apr;87(4):639-48. doi: 10.1124/mol.114.095265. Epub 2015 Jan 9. PubMed PMID: 25576486. 3. Scholten DJ, Roumen L, Wijtmans M, Verkade-Vreeker MC, Custers H, Lai M, de Hooge D, Canals M, de Esch IJ, Smit MJ, de Graaf C, Leurs R. Identification of overlapping but differential binding sites for the high-affinity CXCR3 antagonists NBI-74330 and VUF11211. Mol Pharmacol. 2014 Jan;85(1):116-26. doi: 10.1124/mol.113.088633. Epub 2013 Oct 30. PubMed PMID: 24174496.