| Description | VU661, a redox-active phenazine carboxamide, modulates circadian rhythms by inducing period lengthening. |
| In vitro | VU661(浓度为1、3、10μM;作用时间0-144小时)表现出剂量相关的周期延长作用(10μM时延长约7.2小时),对Bmal1-dLuc U2OS细胞系律动的振幅影响甚微[1]。此外,VU661(浓度为1、10μM;作用时间24小时)在细胞内剂量依赖性地增加光学氧化还原比[1]。同时,VU661对细胞ROS或H2O2水平基本上不产生影响[1]。 |
| molecular weight | 299.33 |
| Molecular formula | C19H13N3O |
| CAS | 37648-76-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |