| Description | VU590 is a potent and moderately selective inhibitor of extrarenal medullary potassium ROMK (Kir1.1).VU590 inhibits Kir7.1 and modulates uterine myometrial contractility and melanocortin signalling. |
| Target activity | Kir7.1:8 μM, Kir1.1:290 nM |
| molecular weight | 488.53 |
| Molecular formula | C24H32N4O7 |
| CAS | 313505-85-0 |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: < 20 mg/mL, Sonication is recommended. H2O: 1 mg/mL (2.05 mM), Sonication is recommended. |
| References | 1. Kharade SV, et al. Pore Polarity and Charge Determine Differential Block of Kir1.1 and Kir7.1 Potassium Channels by Small-Molecule Inhibitor VU590. Mol Pharmacol. 2017 Sep;92(3):338-346. 2. Bhave G, et al. Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol Pharmacol. 2011 Jan;79(1):42-50. |