| Description | VU533 (Nape-Pld activator) is a NAPE-PLD activator with an EC50 value of 0.30 µM.VU533 enhances NAPE-PLD activity and increases macrophage cytosolic burial.VU533 may be used in diseases associated with cardiometabolism. |
| In vitro | VU533 (NAPE-PLD activator) (0.1-30 μM; 24 h) is non-cytotoxic to RAW264.7 and HepG2 cells.[1]VU533 (0.1-30 μM; 24 h) increases NAPE-PLD activity in a concentration-dependent manner in RAW264.7 cells and HepG2 cells.[1]VU533 (10 μM; 6 h) increases efferocytosis of bone marrow-derived macrophages (BMDM) isolated from wild-type mice.[1] |
| Target activity | NAPE-PLD:0.30 μM(EC50) |
| Synonyms | Nape-Pld activator |
| molecular weight | 447.55 |
| Molecular formula | C21H22FN3O3S2 |
| CAS | 923417-09-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 16.67 mg/mL (37.24 mM) |
| References | 1. Zarrow JE, et al. Small Molecule Activation of NAPE-PLD Enhances Efferocytosis by Macrophages. bioRxiv [Preprint]. 2023 Feb 28:2023.01.25.525554. |