| Description | VU0431316 is a negative mGlu5 allosteric modulator. It has activity in a mouse model of anxiety. |
| Synonyms | VU 0431316, VU-0431316 |
| molecular weight | 328.71 |
| Molecular formula | C14H9ClN6O2 |
| CAS | 1620203-63-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Bates BS, Rodriguez AL, Felts AS, Morrison RD, Venable DF, Blobaum AL, Byers FW, Lawson KP, Daniels JS, Niswender CM, Jones CK, Conn PJ, Lindsley CW, Emmitte KA. Discovery of VU0431316: a negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety. Bioorg Med Chem Lett. 2014 Aug 1;24(15):3307-14. doi: 10.1016/j.bmcl.2014.06.003. Epub 2014 Jun 11. PubMed PMID: 24969015; PubMed Central PMCID: PMC4090943. |