| Description | VU-29 is a positive allosteric mGlu5 receptor modulator with EC50=9 nM and Ki=244 nM for rmGluR5. It is selective for mGluR5 relative to other mGluR subtypes (EC50: rmGluR1/rmGluR2=557 nM/1.5 μM; hmGluR4=154 nM). |
| Target activity | mGluR5 (rat):224 nM (Ki), mGluR5 (rat):9 nM (EC50), mGluR2 (rat):1.5 μM (EC50), mGluR4 (human):154 nM (EC50), mGluR1 (rat):557 nM (EC50) |
| Synonyms | VU 29 |
| molecular weight | 384.39 |
| Molecular formula | C22H16N4O3 |
| CAS | 890764-36-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 25 mg/mL (65.04 mM) |
| References | 1. Chen Y , Nong Y , Goudet C , et al. Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses.[J]. Molecular Pharmacology, 2007, 71(5):1389-1398. |