| Description | VU 0364439 is a mGlu4 positive allosteric modulator (C50: 19.8 nM). |
| In vivo | VU 0364439 由于其药代动力学性质不理想，限制了其作为体内工具的应用。相比于RLM（剩余2%），该化合物在HLM中表现出更好的稳定性（剩余63%）。[1] |
| Target activity | mGluR4:19.8 nM(EC50) |
| molecular weight | 422.29 |
| Molecular formula | C18H13Cl2N3O3S |
| CAS | 1246086-78-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: < 1 mg/mL (insoluble or slightly soluble) Ethanol: < 1 mg/mL (insoluble or slightly soluble) DMSO: 79 mg/mL (187.1 mM) |
| References | 1. Engers DW, et al. Bioorg Med Chem Lett, 2010, 20(17), 5175-5178. |