| Description | VRK-IN-1 is a potent and selective inhibitor of cowpox-associated kinase 1 (VRK1), which can be used in the study of neurological disorders. |
| In vitro | VRK-IN-1（3.2μM ;24小时）能略微降低人 HeLa 细胞的活力[1]。 |
| Target activity | VRK1:150 nM (IC50), VRK1:150 nM |
| molecular weight | 349.28 |
| Molecular formula | C18H11F4NO2 |
| CAS | 2378855-09-3 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 80 mg/mL (229.04 mM), Sonication is recommended. |
| References | 1. Serafim RAM, et al. Development of Pyridine-based Inhibitors for the Human Vaccinia-related Kinases 1 and 2. ACS Med Chem Lett. 2019 Aug 19;10(9):1266-1271. |