PeptideDB

VPC12249

CAS No.: 403520-23-0

VPC12249, a lysophosphatidic acid receptor type 1 (LPA1) antagonist, plays a functional role in osteoclast differentiati
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Description VPC12249, a lysophosphatidic acid receptor type 1 (LPA1) antagonist, plays a functional role in osteoclast differentiation and bone resorption activity.
Synonyms VPC-12249, VPC 12249
molecular weight 601.75
Molecular formula C34H52NO6P
CAS 403520-23-0
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
References 1. David M, Machuca-Gayet I, Kikuta J, Ottewell P, Mima F, Leblanc R, Bonnelye E, Ribeiro J, Holen I, Lopez Vales R, Jurdic P, Chun J, Clézardin P, Ishii M, Peyruchaud O. Lysophosphatidic acid receptor type 1 (LPA1) plays a functional role in osteoclast differentiation and bone resorption activity. J Biol Chem. 2014 Mar 7;289(10):6551-64. doi: 10.1074/jbc.M113.533232. Epub 2014 Jan 15. PubMed PMID: 24429286; PubMed Central PMCID: PMC3945319. 2. Gan L, Xue JX, Li X, Liu DS, Ge Y, Ni PY, Deng L, Lu Y, Jiang W. Blockade of lysophosphatidic acid receptors LPAR1/3 ameliorates lung fibrosis induced by irradiation. Biochem Biophys Res Commun. 2011 May 27;409(1):7-13. doi: 10.1016/j.bbrc.2011.04.084. Epub 2011 Apr 23. PubMed PMID: 21545790. 3. Xue J, Gan L, Li X, Li J, Qi G, Wu Y, Fu X, Mao Q, Ao R, Lang J, Lu Y. Effects of lysophosphatidic acid and its receptors LPA⅓ on radiation pneumonitis. Oncol Rep. 2010 Dec;24(6):1515-20. PubMed PMID: 21042747. 4. Xu YJ, Tappia PS, Goyal RK, Dhalla NS. Mechanisms of the lysophosphatidic acid-induced increase in [Ca(2+)](i) in skeletal muscle cells. J Cell Mol Med. 2008 Jun;12(3):942-54. doi: 10.1111/j.1582-4934.2008.00139.x. PubMed PMID: 18494935; PubMed Central PMCID: PMC4401138.