| Description | VPC-80051 is the first small molecule inhibitor of hnRNP A1 splicing activity by using a computer-aided drug discovery approach. |
| In vitro | VPC-80051直接与hnRNP A1 RBD相互作用，并在22Rv1 CRPC细胞系中降低AR-V7信使RNA水平。 |
| molecular weight | 301.29 |
| Molecular formula | C16H13F2N3O |
| CAS | 877969-69-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 55 mg/ml (182.55 mM) |
| References | 1. Carabet LA, et al. Computer-Aided Discovery of Small Molecules Targeting the RNA Splicing Activity of hnRNP A1 in Castration-Resistant Prostate Cancer. Molecules. 2019;24(4):763. Published 2019 Feb 20. |