| Description | Voxelotor (GBT 440) is an inhibitor of sickle hemoglobin (HbS). |
| In vivo | Voxelotor治疗降低了胆红素水平，并改善了黄疸[1]。 |
| Synonyms | GBT 440 |
| molecular weight | 337.37 |
| Molecular formula | C19H19N3O3 |
| CAS | 1446321-46-5 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 125 mg/mL (370.51 mM) |
| References | 1. Impact of voxelotor (GBT440) on unconjugated bilirubin and jaundice in sickle cell disease[J]. Hematology Reports, 2018, 10(2). 2. Hutchaleelaha A , Patel M , Washington C , et al. Pharmacokinetics and Pharmacodynamics of Voxelotor (GBT440) in Healthy Adults and Patients With Sickle Cell Disease[J]. British Journal of Clinical Pharmacology, 2019. |
| Citations | 1. Shu P, You G, Li W, et al.Cefmetazole sodium as an allosteric effector that regulates the oxygen supply efficiency of adult hemoglobin.Journal of Biomolecular Structure and Dynamics.2023: 1-15. |