| Description | Vicriviroc maleate (SCH-417690 (maleate))(Sch-417690) is a piperazine-based CCR5 receptor antagonist with activity against human immunodeficiency virus. The IC50 value is 0.91 nM in clinical development for the treatment of HIV-1. |
| Target activity | CCR5 receptor:0.91 nM |
| Synonyms | 维立韦罗马来酸盐, SCH-D (maleate), SCH-417690 (maleate) |
| molecular weight | 649.7 |
| Molecular formula | C32H42F3N5O6 |
| CAS | 599179-03-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (76.96 mM), Sonication is recommended. H2O: 25 mg/mL (38.48 mM), Sonication and heating are recommended. |
| References | 1. Edward O'Mara, Claudia Kasserra, John Robert Huddlestone,et al. Antimicrob Agents Chemother. 2010; 54(6): 2448-2454. 2. Sanjay Bhattacharya, Husam Osman. Novel targets for anti-retroviral therapy. Journal of Infection. 2009,59(6): 377-386. 3. Maltêz, Fernandoa; Doroana, Manuelab; Branco, Teresac et al. Current Opinion in HIV & AIDS. 2011 ,6:S21-S30. |